Therapeutic Perspectives in Type-1 Diabetes


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SGLT2 inhibitors in combination therapy: from mechanisms to clinical considerations in type 2 diabetes management. Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats. J Pharm Pharmacol. SGLT inhibitor adjunct therapy in type 1 diabetes. The enteroinsular axis — contribution to obesity-diabetes and its treatments. Once-weekly exenatide as adjunct treatment of type 1 diabetes mellitus in patients receiving continuous subcutaneous insulin infusion therapy.

Can J Diabetes. Twelve-week treatment with liraglutide as add-on to insulin in normal-weight patients with poorly controlled type 1 diabetes: a randomized, placebo-controlled, double-blind parallel study. Anti-IL monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes.

A new perspective on metformin therapy in type 1 diabetes | SpringerLink

J Autoimmun. Pocai A. Action and therapeutic potential of oxyntomodulin. Mol Metab. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Sustained treatment with a stable long-acting oxyntomodulin analogue improves metabolic control and islet morphology in an experimental model of type 1 diabetes. Differential expression of glucagon-like peptide-2 GLP-2 is involved in pancreatic islet cell adaptations to stress and beta-cell survival.

Islet distribution of peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival. Transplantation of porcine fetal pancreas to diabetic patients. Microbiological safety of the first clinical pig islet xenotransplantation trial in New Zealand.

Therapeutic Perspectives in Type-1 Diabetes

Differentiation of transplanted microencapsulated fetal pancreatic cells. A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets. Overcoming the barriers to xenotransplantation: prospects for the future. Transplantation of intact pancreatic islets in rats.

Transplantation of dispersed pancreatic islet tissue in humans: autografts and allografts. Automated method for isolation of human pancreatic islets.

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. Insulin-heparin infusions peritransplant substantially improve single-donor clinical islet transplant success. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation.

The future of islet transplantation is now. Front Med Lausanne. Update on islet transplantation.

Cold Spring Harb Perspect Med. The journey of islet cell transplantation and future development. The state of the art of islet transplantation and cell therapy in type 1 diabetes.


  • Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives.
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Acta Diabetol. Korsgren O. Islet encapsulation: physiological possibilities and limitations. Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain.

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Endocr Rev. Establishment of insulin-producing cells from human embryonic stem cells underhypoxic condition for cell based therapy. Front Cell Dev Biol. Approaches in immunotherapy, regenerative medicine, and bioengineering for type 1 diabetes. Am J Transplant. Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply. Sci Rep. Biotechnol J. Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes.

Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. The combined expression of Pdx1 and MafA with either Ngn3 or NeuroD improve the differentiation efficiency of mouse embryonic stem cells into insulin-producing cells. Cell Transplant.


  1. Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes. - Semantic Scholar;
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  3. The Opening Act: Canadian Theatre History 1945-1953;
  4. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol. A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. Functional beta cell mass from device-encapsulated hESC-derived pancreatic endoderm achieving metabolic control.

    Stem Cell Reports. Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells. Stem Cell Res. Nat Commun. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.

    Song J. Development of auto antigen-specific regulatory T cells for diabetes immunotherapy. Immune Netw.

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    Evidence for instant blood-mediated inflammatory reaction in clinical autologous islet transplantation. Alloimmune monitoring after islet transplantation: a prospective multicenter assessment of 25 recipients. Assessing the effect of immunosuppression on engraftment of pancreatic islets. Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? Curr Diab Rep. Survival and function of mesenchymal stem cells MSCs depend on glucose to overcome exposure to long-term, severe and continuous hypoxia.

    J Cell Mol Med. Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications. J Immunol Res. Co-transplantation of islets with mesenchymal stem cells in microcapsules demonstrates graft outcome can be improved in an isolated-graft model of islet transplantation in mice. Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Hypoxia-induced damage in human islets is reduced with the use of mesenchymal stem cell-preconditioned medium.

    Transplant Proc. Combinatorial human progenitor cell transplantation optimizes islet regeneration through secretion of paracrine factors. Stem Cells Dev.

    Therapeutic Perspectives in Type-1 Diabetes

    Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is beneficial for transplantation outcome in diabetic mice. Microchip-based engineering of super-pancreatic islets supported by adipose-derived stem cells. Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells. Human adipose-derived mesenchymal stem cells respond to short-term hypoxia by secreting factors beneficial for human islets in vitro and potentiate antidiabetic effect in vivo.

    Cell Med. Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function. Stem Cell Res Ther. Gene Ther. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Molecular analysis of endothelial progenitor cell EPC subtypes reveals two distinct cell populations with different identities. BMC Med Genomics. Identification of blood vascular endothelial stem cells by the expression of protein C receptor. Cell Res. Endothelial progenitors: a consensus statement on nomenclature.

    Stem Cells Transl Med. The vasoreparative potential of endothelial colony forming cells: a journey through pre-clinical studies. Endothelial colony-forming cell coating of pig islets prevents xenogeneic instant blood-mediated inflammatory reaction. The potential of endothelial colony-forming cells to improve early graft loss after intraportal islet transplantation.

    Circ Res. Fadini GP, Avogaro A. Diabetes impairs mobilization of stem cells for the treatment of cardiovascular disease: a meta-regression analysis. Int J Cardiol. Hematopoietic stem cell mobilization is necessary but not sufficient for tolerance in islet transplantation. Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus. Restoring stem cell mobilization to promote vascular repair in diabetes.

    Vascul Pharmacol. Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study. Cardiovasc Diabetol.

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    1. A New Perspective On Metformin Therapy In Type 1 Diabetes?
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    4. Once daily s. Patients, who received a combination of once daily fast-acting and basal insulin, demonstrated a similar HbA1c level and significantly better treatment satisfaction as compared with basal insulin alone. Long-lasting reduction in HbA1c and improved psychosocial responses observed in patients using insulin pump. Adjusting insulin and glucagon delivery using dual-hormone artificial pancreas at exercise onset significantly reduced hypoglycaemia. Delivering insulin and glucagon using dual-hormone artificial pancreas demonstrated better nocturnal glycaemic control.

      Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes. Although their immunomodulatory properties are not yet completely understood, their low immunogenic potential together with their effects on immune response make them a promising therapeutic tool for severe refractory autoimmune diseases. View on PubMed. Alternate Sources. Save to Library. Create Alert. Share This Paper. Figures, Tables, and Topics from this paper. Figures and Tables. Citations Publications citing this paper. Furthermore, the tables include concise and easy-to-understand information on current clinical trials.

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