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COMBINATORIAL CHEMISTRY AND SOLID PHASE SYNTHESIS
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Combinatorial chemistry | Nature Biotechnology
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Finding the active compound. Screening mixtures for biological activity has been compared to finding a needle in a haystack. In the past, chemists have traditionally made one compound at a time.
Figure The range of combinatorial techniques is highly diverse, and these products could be made individually in a parallel or in mixtures, using either solution or solid phase techniques. Whatever the technique used the common denominator is that productivity has been amplified beyond the levels that have been routine for the last hundred years. Combinatorial chemistry-a technology for creating molecules en masse and testing them rapidly for desirable properties-continues to branch out rapidly.
Compared with conventional one-molecule-at-a-time discovery strategies, many researchers see combinatorial chemistry as a better way to discover new drugs, catalysts and materials. The development of new processes for the generation of collection of structurally related compounds libraries with the introduction of combinatorial approaches has revitalized random screening as a paradigm for drug discovery and has raised enormous excitement about the possibility of finding new and valuable drugs in short times and at reasonable costs.
Principle characteristics of conventional vs. The resin you use is often affected by the reaction types available and care must be taken so that the attachment of the reagent to the substrate and bead are unaffected. Each reaction step has to be carefully planned, and often a reaction isn't available because the chemistry affects the resin. There is a great deal of diversity created, but not often a central synthetic idea in the libraries. One can argue that there should be a focus on the type of molecule developed in order to maximize hits.
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- Introduction to the Theory of Complexity (Prentice Hall International Series in Computer Science).
It has been applied to drug design for an even shorter period of time. The origins of combinatorial chemistry can be traced back at least as far as , when biochemistry professor R. For his work on solid-phase synthesis, Bruce Merrifield won the Nobel Prize in chemistry in During this time, automated peptide synthesizer technology was in its infancy, and the preparation of individual peptides was a challenge. The field in its modern dimensions only began to take shape in the s, when in research scientist H. Another early pioneer was Dr.
In the s, the focus of the field changed predominantly to the synthesis of small, drug like Organic com-pounds and many pharmaceutical companies and biotechnology firms now use it in their drug discovery efforts.
Related Solid phase synthesis and combinatorial technologies
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