Figure 1 Schematic representation of the blood-brain barrier and aptamers toward targeted therapy of neurological diseases Rakesh, The most lethal form of malignant tumour in adults is glioblastoma. This type of tumour is characterised by rapid growth and is highly invasive with its capacity to spread into critical neurological areas within the brain. In , Kang et al. Kim et al was also able to develop tumour initiating cells TIC aptamers that specifically bind to TICs with excellent affinity.
These aptamers select and internalize into Glioblastoma GBM cells that self-renew, proliferate, and initiate tumours Kim et al.
Publications: Veedu, Rakesh
PEG—PLGA nanoparticles incorporating a DNA aptamer to target nucleolin, a molecule that is highly expressed in the plasma membrane of both cancer cells and tumour endothelium enhanced the anti-proliferative effects of paclitaxel against C6 glioma cells in vitro Srikanth and Kessler, These aptamer nanoparticles strikingly reduced C6 glioma xenograft volumes in nude mice, and prolonged survival of animals with C6 intracranial gliomas compared with treatment with either paclitaxel alone or paclitaxel loaded into undecorated nanoparticles.
Srikanth and Kessler, Importantly, the aptamer-decorated nanoparticles showed greater efficacy than undecorated particles highlighting the value of targeted delivery Srikanth and Kessler, Aptamer Group takes a high-throughput approach using liquid handling robotics and dedicated researchers to identify aptamers against novel and significant targets.
We are committed to finding the perfect aptamers to your target and use a proprietary selection technique to identify high affinity aptamers with specificity in as short as 3 months.
Through our know-how and key collaborators, we are able to help facilitate the development of aptamers as therapeutics or diagnostic devices for your target of interest. White paper :- Our white paper on Aptamers in Neuroscience will be posted on the website soon. Because oxidized linoleic acid metabolites are released during cell injury, these findings suggest a mechanism for integrating the hyperalgesic and proinflammatory roles of TRPV1 and linoleic acid metabolites and may provide the foundation for investigating new classes of analgesic drugs.
- Airpower & the Cult of the Offensive.
- Rickettsial Diseases.
- Aptamers in bacterial, viral, and parasitic disease (2016).
- Radiation Detection and Measurement.
- Reconceiving the Gene: Seymour Benzers Adventures in Phage Genetics.
- Britains New Towns: Garden Cities to Sustainable Communities?
- Nano based drug delivery systems: recent developments and future prospects.
Amol M. Patwardhan, Armen N. Akopian, Nikita B. Ruparel, Anibal Diogenes, Susan T. Weintraub, Charis Uhlson, Robert C.
Cell-SELEX-based aptamer-conjugated nanomaterials for enhanced targeting of cancer cells
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